Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua.
The evolution of insect resistance to insecticides is frequently associated with overexpression of one or more cytochrome APRICOT SCRUB P450 enzyme genes.Although overexpression of CYP450 genes is a well-known mechanism of insecticide resistance, the underlying regulatory mechanisms are poorly understood.Here we uncovered the mechanisms of overexpr